Relationship Between Rearrangement and Transcription of the T - Cell Receptor a , fi , and ‘ y Genes in B Precursor Acute Lymphoblastic Leukemia
نویسندگان
چکیده
Transcription of the T-cell receptor (TCR)-y. . and a genes has been analyzed in 29 patients with B-precursor acute lymphoblastic leukemia (ALL) by northern blotting analysis. In addition. the configuration of the TCR-a gene was examined using newly developed genomic Ja probes capable of detecting TCR-a gene rearrangements involving joining (J)a regions up to 85 kilobase (kb) from constant (C)a. In this study. TCR-a gene rearrangements were detected in 1 6 of the 29 patients. Thus, the frequency of TCR-a gene rearrangements in B precursor ALL was as high as with TCR-y (1 5 of 29) and was higher than observed for TCR-fi (nine of 29). Truncated transcripts
منابع مشابه
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